The deftly landed quip – so perfectly timed it deserves its own rim shot – is one of the few printable lines from “Notorious C.H.O.,” a raunchy and frequently hilarious follow-up to the gifted Korean American stand-up’s “I’m the One That I Want,” the 2000 concert film in which Cho related her losing battle with weight and her attempt to break into the mainstream with the ill-fated sitcom “All-American Girl.”

It would be hard to top the brilliant and acerbic humor of that confessional film but, frankly, Cho doesn’t need to. Filmed in front of a screaming house of die-hard Seattle fans, “Notorious” doesn’t always fire on all cylinders, but her jokes – if the sometimes rambling monologues about male menstruation and a lesbian encounter with a much taller woman can be called jokes – are met with the raucous and universal approval due a goddess by her acolytes.

Cho relates her experience with colonic irrigation. (Just picture an attendant inserting the hose in the wrong orifice – on second thought, don’t.) She also relates, while doing an impression of her mother’s heavily accented English – a Cho trademark – a long-winded account that has something to do with her father and homosexuality. When she starts channeling “Mommy,” though – who, by the way is shown sitting in the audience laughing uproariously – it hardly matters what she’s talking about or where the story is going. Cho’s parental characterization is so funny (and, based on the preconcert interview with her folks, accurate) it makes your cheeks hurt.

Where “Notorious” fails to measure up to “I’m the One,” however, is in its agenda. While the first film had a kind of cohesive, organic narrative and a thematic message about self-esteem, in this go-round Cho’s in it more for the laughs than the lesson.

Nevertheless, she still manages to shoehorn in an unwieldy, and unnecessarily earnest, speech near the end about the worth of all God’s creatures: persons of color, persons of size, lesbians, gays, etc.

Margaret, we love that your humor cuts so close to the bone, and we love the fact that we can all learn something about ourselves from your comedy. For crying out loud, you’re practically the patron saint of anyone who has ever felt like an outsider. You don’t need to keep reminding us of that. Sometimes it’s enough just to bust a gut.