Chris Rock, “Mr. Show,” “Monty Python’s Flying Circus,” John Belushi, Bernie Mac, “Mystery Science Theater 3000,” Ian Frazier’s “Dating Your Mom,” www.theonion.com, “Best in Show,” Chris Farley, the wedding prank involving a live lobster and the honeymoon suite, “Animal House,” Woody Allen before 1980, “Springtime for Hitler,” Chris Kattan doing Mr. Peepers, “The Simpsons,” the time my brother got a peanut stuck up his nose, “Tootsie,” Roseanne Rosannadanna, “La Cage Aux Folles,” David Sedaris’ “Me Talk Pretty One Day,” “There’s Something About Mary,” Will Ferrell, “This Is Spinal Tap,” Steve Martin’s New Yorker essays, Ozzy searching for the cat in his backyard, “Seinfeld,” the “Saturday Night Live” parody of “It’s a Wonderful Life,” “The Tom Green Show,” the tent scene in “Austin Powers: The Spy Who Shagged Me,” the video Bill Clinton put together for the White House correspondents’ dinner, and that old chestnut - the dog, the toddler, and the garden hose on “America’s Funniest Home Videos.”

Sorries all around, but Margaret rules.

“Thank you,” says the ever-demure Cho when informed of this mother of all buttock-bussers.

Not only does “The Notorious C.H.O.” make you laugh till your spleen bleeds, it’s also perfectly functional as a postdoctorate-level lesson in sexual education.

Cho is not shy.

“Drugs, sex - these are things people want to talk about,” Cho says. “Those things make us individuals, because everybody has their own take.

“If there’s anything that’s taboo, I haven’t come across it,” she says, then adds thoughtfully, “Boring. Boring is taboo. That’s the only thing. There’s a need for the material to be something that incites discussion or a riot. I want a reaction.”

On the surface, “The Notorious C.H.O.” is much like Cho’s last film, 2000’s critical and mini-financial hit, “I’m the One That I Want.” In both, Cho says funny things to a theater filled with adoring fans.

But “The Notorious C.H.O.,” which opens in Manhattan Wednesday, finds the 33-year-old San Francisco native in a different orbit.

The central themes of “I’m the One That I Want” were Cho’s battle with alcohol and drugs and the war she fought with herself and the ABC network over her sitcom, “All-American Girl,” which lasted but one season in 1994.

“I’m the One That I Want” was wild and original and funny as all get out, but, with its stories of kidney failure, mystery bed stains, and contemplated suicide, its thrust was catharsis.

“The Notorious C.H.O.” feels like Cho’s trucked all that garbage out to the curb and is free to rock on with her frock on.

“Now I’m just being funny,” she says.

With “The Notorious C.H.O.” in theaters, Cho plans to spend the summer holed up in her house in Glendale, in suburban Los Angeles, supervising renovation work, writing a script for a fictional film, and using HGTV as a procrastination tool.

“People on that channel have terrible taste,” Cho says admiringly, with apologies to nothing and no one.